REDUCTION IN CARDIOLIPIN REDUCES EXPRESSION OF CREATINE TRANSPORTER-1 AND CREATINE TRANSPORT IN GROWING HCMEC/D3 HUMAN BRAIN MICROVESSEL ENDOTHELIAL CELLS

The phospholipid cardiolipin (CL) regulates mitochondrial energy production.Endothelial cells of the blood-brain barrier (BBB) play a vital role in uptake of metabolites into the brain and are enriched in mitochondria.We examined how deficiency in BBB endothelial cell CL regulates the expression of selected drug and metabolite transporters and thei

Post-anthesis phosphorus (P) uptake and the remobilization Cereal Bowl of the previously acquired P are the principal sources of grain P nutrition in wheat.However, how the acquired P reaches the grains and its partitioning at the whole plant level remain poorly understood.Here, the temporal dynamics of the newly acquired P in durum wheat organs an

The gas industry Air Purifier relies on indirect heating to prevent gas from freezing when it is transferred from high-pressure networks to lower pressure distribution systems.The main challenge in preheating natural gas is designing an indirect heating system capable of consistently maintaining a target temperature, despite large load diversity.Th

In the Meat Alternatives first part of this dissertation, selected models and standards from Germany and the USA were introduced, based on a literature review and thus revealing what is considered relevant for practice in a variety of sources and which competencies preservice teachers should acquire, according to these sources.In the second part, m

Transitional disks are protoplanetary disks with large Air Purifier and deep central holes in the gas, possibly carved by young planets.Dong & Dawson simulated systems with multiple giant planets that were capable of carving and maintaining such gaps during the disk stage.Here we continue their simulations by evolving the systems for 10 Gyr after d